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PROLOR: The Added Value Of Reversible PEGYlation

  Wednesday, March 30, 2011

When Professor Irving Boime and his team at Washington University in St. Louis observed that human chorionic gonadotropin (hCG) has a longer half life than other natural hormones, researchers’ curiosity led them to discover that a carboxyl terminal peptide (CTP) linked to the hormone molecule increases its half life. Experimenting with CTP on other proteins left no doubt in the minds of the researchers that linking Nature’s CTP to protein therapeutics could be safe and effective in extending their half-life. When it comes to reproduction, Mother Nature does not err and does not cause harm. It selected CTP to link to the hormone, which without it, pregnancy would have never been possible. Read also The Value of CTP Technology  More...

Prolor Biotech (PBTH): The Value Of CTP Technology.

  Saturday, October 09, 2010

PROLOR Biotech (PBTH) uses a novel, elegant, safe and effective approach to prolonging the half-life in circulation of therapeutic proteins molecules. The method involves adding a naturally occurring peptide, carboxyl terminal peptide (CTP), to the protein molecule. By embarking on this strategy, Prolor is in fact mimicking Mother Nature, which attached CTP to human chorionic gonadotropin (hCG) hundreds of thousands of years ago to extend its life span. hCG is a hormone secreted from conception and throughout pregnancy. It induces uterine changes and is essential for maintaining pregnancy.  More...


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